North East and North Cumbria
ICS Formulary
4 Central nervous system
04-06 Domperidone and metoclopramide
Metoclopramide
Formulary
Please refer to MHRA advice
Metoclopramide: risk of neurological adverse effects
Domperidone
Formulary
Approved for use as a galactagogue to re-establish breastfeeding on specialist advice and following a cardiovascular risk assessment in light of MHRA advice.
MHRA Drug Safety Alert (May 2014): Domperidone: risk of cardiac side effect
MHRA Drug Safety Update (Dec 2019): Domperidone for nausea and vomiting: lack of efficacy in children; reminder of contraindications in adults and adolescents
Links
Chemotherapy Induced Nausea and Vomiting (CINV) Anti-emetic Guidelines
Chemotherapy Induced Nausea and Vomiting (CINV) Anti-emetic Guidelines
Metoclopramide: risk of neurological adverse effects
MHRA Drug Safety Alert (Feb 2015): Drugs and driving: blood concentration limits set for certain drugs
MHRA Drug Safety Alert (Jul 2013): Ondansetron for intravenous use: dose-dependent QT interval prolongation
MHRA Drug Safety Alert (May 2014): Domperidone: risk of cardiac side effect
MHRA Drug Safety Update (Dec 2019): Domperidone for nausea and vomiting: lack of efficacy in children; reminder of contraindications in adults and adolescents
MHRA Drug Safety Update (Jan 2020): Ondansetron: small increased risk of oral clefts following use in the first 12 weeks of pregnancy
MHRA Drug Safety Update (Jan 2020): Ondansetron: small increased risk of oral clefts following use in the first 12 weeks of pregnancy
NENC Palliative and End of Life Care Symptom Control Guidelines
NICE CG84: Vomiting and diarrhoea in children under 5
NICE NG155: Tinnitus: assessment and management
NICE NG62: Cerebral palsy in under 25s: assessment and management
NICE TA614: Cannabidiol with clobazam for treating seizures associated with Dravet syndrome
NICE TA615: Cannabidiol with clobazam for treating seizures associated with Lennox–Gastaut syndrome
TEWV - Medicines Optimisation – Interactive Guide
TEWV Guidelines
TEWV Safe Transfer of Prescribing Guidance
Key
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