North East and North Cumbria
ICS Formulary
 
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8 Malignant disease and immunosuppression
08-01-02 Anthracyclines and other cytotoxic antibiotics

Bleomycin
Formulary
  • Also approved for use in intralesional sclerotherapy in the treatment of low-flow vascular lesions. unlicensedunlicensed indication

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Dactinomycin
Formulary

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Daunorubicin
Formulary
  • The following formualtions are approved:
    • 20mg injection;
    • 10mg, 15mg, 35mg;
    • 40mg prefilled syringes.

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Doxorubicin
Formulary
  • Doxorubicin 50mg injection - includes use with DC Beads for use in transcatheter arterial chemoembolisation (TACE) therapy in patients with hepatocellular cancer. 
  • Doxorubicin 20mg & 50mg pegylated liposomal injection - approved for second-line (or subsequent) treatment in advanced ovarian cancer in line with NICE. 
  • Approved for the treatment of recurrent ovarian cancer in line with NICE.
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
Link  MHRA Drug Safety Update (July 2020): Liposomal�and�lipid- complex�formulations:�name�change�to�reduce�medication errors

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Epirubicin
Formulary
  • Note: epirubicin 100mg injection is unlicensedunlicensed.

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Idarubicin
Formulary
  • Approved formulations include:
    • 5mg and 10mg capsules;
    • 10mg injection.

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Mitomycin
Formulary
  • Also approved for treatment in combination with 5-Fluorouracil for bladder cancer concurrent with radiotherapy.
  • Mitomycin 0.04% preservative free eye drops  are also approved for use - unlicensedunlicensed.

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Mitoxantrone
Formulary

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Pixantrone
Formulary
  • Approved as a possible treatment for adults with multiply relapsed or refractory aggressive non-Hodgkin's B cell lymphoma if they have previously been treated with rituximab and they are having third- or fourth-line treatment in line with NICE. 
Link  NICE TA306: Pixantrone monotherapy

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