| Formulary Chapter 5: Infections - Full Chapter
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| Chapter Links... |
 COVID-19 Therapeutic Alert |
| Interim Clinical Commissioning Policy: Antivirals or neutralising monoclonal antibodies in the treatment of COVID-19 in hospitalised patients (Version 5 - effective from 10th February 2022) |
 NENC ICB - Cellulitis Diagnosis and Management in Ambulatory Adults in primary care; Supporting Information |
| NICE NG15: Antimicrobial stewardship: systems and processes for effective antimicrobial medicine use |
| NICE NG63: Antimicrobial stewardship: changing risk-related behaviours in the general population |
| North of Tyne, Gateshead and North Cumbria - Antibiotic and Diagnostic quick reference tools |
| Primary Care Antimicrobial Guidelines |
| TEWV: Antibiotic Prescribing Procedure |
| UK Interim Clinical Commissioning Police - Therapies for patients with symptomatic hospital-onset COVID-19 |
| Details... |
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HIV infection |
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Nucleoside reverse transcriptase inhibitors |
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Protease inhibitors |
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Non-nucleoside reverse transcriptase inhibitors |
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Other antiretrovirals |
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Pharmacokinetic enhancers of anti-retrovirals |
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Combination Products |
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Abacavir & Lamivudine
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Formulary
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Abacavir & Lamivudine & Zidovudine
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Formulary
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Abacavir & Lamivudine & Dolutegravir
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Formulary
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Dolutegravir Sodium & Lamivudine (Dovato®)
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Formulary
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- Film-coated tablet containing dolutegravir sodium equivalent to 50 mg dolutegravir and 300 mg lamivudine
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Dolutegravir Sodium & Rilpivirine Hydrochloride (Juluca®)
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Formulary
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- Film-coated tablets containing dolutegravir sodium (equivalent to 50 mg dolutegravir) and rilpivirine hydrochloride (equivalent to 25 mg rilpivirine)
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Emtricitabine & Tenofovir Disoproxil
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Formulary
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- Tablets: Emtricitabine 200 mg and Tenofovir disoproxil (as fumarate) 245 mg
- Use generic preparation in preference to the branded product (Truvada®)
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Emtricitabine & Rilpivirine & Tenofovir disoproxil (Eviplera®)
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Formulary
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- Tablets: 200 mg / 25 mg / 245 mg
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Lopinavir and Ritonavir (Kaletra®)
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Formulary
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Tenofovir Disproxil & Cobicistat & Elvitegravir & Emtricitabine
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Formulary
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- To be used in accordance with NHS England Clinical Commissioning Policy.
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Tenofovir Disproxil & Efavirenz & Emtricitabine
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Formulary
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Emtricitabine & Elvitegravir & Cobicistat & Tenofovir alafenamide (Genvoya®)
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Formulary
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- Tablet: 200mg / 150 mg / 150 mg / 10 mg
- To be used in accordance with NHS England Clinical Commissioning Policy.
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Emtricitabine & Rilpivirine & Tenofovir alafenamide (Odefsey®)
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Formulary
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- Film coated tablets containing rilpivirine 25mg, emtricitabine 200mg & tenofovir alafenamide (as fumarate) 25mg
- To be used in accordance with NHS England Clinical Commissioning Policy.
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Emtricitabine & Tenofovir alafenamide (Descovy®)
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Formulary
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- Film coated tablets containing:
- emtricitabine 200mg & tenofovir alafenamide (as fumarate) 10mg
- emtricitabine 200mg & tenofovir alafenamide (as fumarate) 25mg
- To be used in accordance with NHS England Clinical Commissioning Policy.
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Zidovudine & Lamivudine
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Formulary
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Key |
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Restricted Drug |
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Unlicensed |
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Link to adult BNF
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Link to children's BNF
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Link to SPCs
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Cytotoxic Drug |
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Controlled Drug |
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High Cost Medicine |
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NHS England |
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Homecare |
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ICB |
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Low carbon footprint |
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Medium carbon footprint |
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High carbon footprint |
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Description |
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Drugs for hospital use only. The responsibility for initiation and monitoring treatment should rest with an appropriate hospital clinician and the drug should be supplied through the hospital throughout the duration of treatment. In some very exceptional circumstances (e.g. due to distance from the hospital, storage, supply or mobility/transport problems) it may be appropriate for the GP to be asked to prescribe a Red drug. This should be negotiated on an individual patient basis and should only be done with the GP’s prior informed agreement where the roles of the GP and hospital services are clearly defined and agreed. The GP should not feel under pressure to prescribe in these circumstances. For all RED drugs automatically added to the formulary in response to a positive NICE TA: Prescribers need to ensure that local Trust new drug governance procedures and pharmacy processes are followed before any prescribing. |
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Drugs initiated by hospital specialist, but where continuing treatment by GPs may be appropriate under a shared care arrangement. These medicines are considered suitable for primary care prescribing following specialist initiation of therapy and stabilisation, with ongoing communication between the primary care prescriber and specialist as set out in the associated shared care guideline (SCG). Shared care should be initiated by the specialist, which includes consultant, suitably trained specialist non-medical prescriber or GPwER within a secondary, tertiary, or primary care clinic.
The specialist should send the primary care prescriber a copy of the NENC Clinical Effectiveness and Governance (CEG) Subcommittee approved SCG to sign. The primary care prescriber should sign the SCG or indicate reasons why they are unable to accept the agreement and return a copy back to the specialist, as soon as possible.
SCGs are available or are being developed for most of the drugs listed as AMBER. |
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Drugs normally recommended or initiated by a hospital specialist who is a prescriber, a GP with an extended role [GPwER], or a specialist within primary care which can be safely maintained in primary care and monitored in primary care. In some cases, a further restriction for use may be defined. The primary care prescriber must be familiar with the drug to take on prescribing responsibility or must obtain the required information from the specialist. Therefore, provision of additional information, or an information leaflet, may be appropriate in some cases to facilitate continuing treatment by primary care prescriber or provide information re stopping criteria.
These are considered suitable for primary care prescribing following specialist assessment and recommendation of therapy, with ongoing communication between the primary care prescriber and specialist, if necessary.
In some case these drugs require specialist initiation and short to medium term monitoring of efficacy or toxicity until the patient’s dose is stable. Following specialist review the patient may be transferred to primary care for ongoing prescribing. Ongoing prescribing by primary care can include, if required, additional dose titrations and assessment of efficacy, with ongoing communication between the primary care prescriber and specialist, if necessary.
If the drug requires urgent initiation, it is expected that the specialist undertakes the initial prescribing responsibility for an appropriate period of time, usually a minimum of 28 days. A GREEN+ drug can only be recommended to primary care for initiation if does not need to be initiated within 28 days. |
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Medicines suitable for initiation, ongoing prescribing and discontinuation in all care settings, subject to appropriate communication between those responsible. |
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UNDER REVIEW: drugs whose current formulary status or RAG status is currently under review. |
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Drugs that have been considered by the NENC Clinical Effectiveness and Governance (CEG) Subcommittee (or other approved body) and are not approved for prescribing within the North East and North Cumbria ICS. These may also include all medicines with a “not NHS” or “DLCV” classification in the BNF, those agents as included within the NICE “Do not do” list, and those agents included with the NHS England: Items which should not routinely be prescribed in primary care. |
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