North East and North Cumbria
ICS Formulary
 
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10 Musculoskeletal and joint diseases
10-01-03 Drugs which suppress the rheumatic disease process

Baricitinib Olumiant®
Formulary
  • Approved for the treatment of moderate to severe rheumatoid arthritis in adults in line with NICE.
  • Approved for use in monogenic interferonopathis in adults and children 2 years and over in line with NHS England Clinical Commissioning Policy.

 

Link  Clinical Commissioning Policy Baricitinib for use in monogenic interferonopathies (adults and children 2 years and over) (210506P)
Link  Clinical Commissioning Policy: Baricitinib for patients hospitalised due to COVID-19 (adults and children aged 2 years and over)
Link  MHRA Drug Safety Update (April 2023): Janus kinase (JAK) inhibitors: new measures to reduce risks of major cardiovascular events, malignancy, venous thromboembolism, serious infections and increased mortality
Link  MHRA Drug Safety Update (Aug 2020): Baricitinib (Olumiant▼): increased risk of diverticulitis, particularly in patients with risk factors
Link  MHRA Drug Safety Update (Mar 2020): Baricitinib (Olumiant▼): risk of venous thromboembolism
Link  NICE TA466: Baricitinib for moderate to severe rheumatoid arthritis
Link  NICE TA681: Baricitinib for treating moderate to severe atopic dermatitis

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Filgotinib Jyseleca®
Formulary
  • Approved for treating moderate to severe rheumatoid arthritis in line with NICE

 

Link  MHRA Drug Safety Update (April 2023): Janus kinase (JAK) inhibitors: new measures to reduce risks of major cardiovascular events, malignancy, venous thromboembolism, serious infections and increased mortality
Link  NICE TA676: Filgotinib for treating moderate to severe rheumatoid arthritis
Link  NICE TA792: Filgotinib for treating moderately to severely active ulcerative colitis

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Tofacitinib Xeljanz®
Formulary
  • 5mg and 10mg tablets.
  • Approved for treating junveline idiopathic arthritis in line with NICE
  • Approved for the treatment of active psoriatic arthritis after inadequate response to DMARDs in line with NICE.
  • Approved for the treatment of moderate to severe rheumatoid arthritis in adults in line with NICE.
  • Approved for for treating active ankylosing spondylitis in line with NICE
Link  MHRA Drug Safety Update (April 2023): Janus kinase (JAK) inhibitors: new measures to reduce risks of major cardiovascular events, malignancy, venous thromboembolism, serious infections and increased mortality
Link  MHRA Drug Safety Update (Mar 2020): Tofacitinib (Xeljanz▼): new measures to minimise risk of venous thromboembolism and of serious and fatal infections
Link  MHRA Drug Safety Update (May 2019): Tofacitinib (Xeljanz▼): restriction of 10 mg twice-daily dose in patients at high risk of pulmonary embolism while safety review is ongoing
Link  NICE TA480: Tofacitinib for moderate to severe rheumatoid arthritis Technology appraisal guidance
Link  NICE TA543: Tofacitinib for treating active psoriatic arthritis after inadequate response to DMARDs
Link  NICE TA547: Tofacitinib for moderately to severely active ulcerative colitis
Link  NICE TA735: Tofacitinib for treating juvenile idiopathic arthritis
Link  NICE TA920: Tofacitinib for treating active ankylosing spondylitis

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Minocycline
Formulary
  • Only approved for use in patients with rheumatoid arthritis who are unable to tolerate biologics and other DMARDs.

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Baricitinib
Non Formulary
  • Not recommended for treating juvenile idiopathic arthritis in people 2 years and over in line with NICE
Link  NICE TA982: Baricitinib for treating juvenile idiopathic arthritis in people 2 years and over (terminated appraisal)

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