North East and North Cumbria
ICS Formulary
2 Cardiovascular system
02-05-05-01 Angiotensin-converting enzyme inhibitors (ACE inhibitors)
Lisinopril
First Choice
Ramipril
First Choice
Most cost effective formulation to be prescribed
Enalapril
Formulary
For use in breastfeeding mothers only. Breastfeeding mothers should be converted to ramipril when they are no longer breastfeeding.
Perindopril erbumine
Formulary
Perindopril is third line for all indications including prevention of stroke.
Note: Perindopril arginine is classified as BLACK - not approved.
Items not to be routinely prescribed in primary care
Captopril
Formulary
Treatment should only be on the advice of a hospital paediatrician.
5mg in 5ml suspension are also approved for use.
2mg capsules are also approved for use
unlicensed.
Links
Academic Health Science Network (North East and North Cumbria) - Atrial Fibrilation
County Durham and Darlington DVT Pathway Information
County Durham and Tees Valley Prescribing Guideline for the Use of Anticoagulants in Non-Valvular Atrial Fibrillation
Items not to be routinely prescribed in primary care
MHRA Drug Safety Update (Dec 2016): Spironolactone and renin-angiotensin system drugs in heart failure: risk of potentially fatal hyperkalaemia—clarification, December 2016
MHRA Drug Safety Update (Feb 2016): Spironolactone and renin-angiotensin system drugs in heart failure: risk of potentially fatal hyperkalaemia.
MHRA Drug Safety Update (June 2014): Combination use of medicines from different classes of renin-angiotensin system blocking agents: risk of hyperkalaemia, hypotension, and impaired renal function—new warnings
NICE ES24: COVID-19 rapid evidence summary: angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) in people with or at risk of COVID-19
NICE NG148: Acute kidney injury: prevention, detection and management
NICE NG185: Acute coronary syndromes
NICE NG191: COVID-19 rapid guideline: managing COVID-19
North Cumbria - Cardiovascular workplan 2022
South Tees Hospitals Cardiology drug prescribing guidelines & formulary
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