North East and North Cumbria
ICS Formulary
4 Central nervous system
04-08-01 Other Drugs
Cenobamate
Ontozry
®
Formulary
12.5mg, 25mg, 50mg, 100mg, 150mg and 200mg tablets
Approved for treating focal onset seizure in epilepsy in line with NICE
Patients will be stabilised by the epilepsy specialist prior to transfer to the GP for continuation. This will usually be after 3 months of treatment.
NICE TA753: Cenobamate for treating focal onset seizures in epilepsy
Links
Local Shared Care guideline in TEWV to support Valproate Pregnancy Prevention Programme
MHRA Drug Safety Alert (Feb 2015): Drugs and driving: blood concentration limits set for certain drugs
MHRA Drug Safety Alert (Oct 2017): Gabapentin (Neurontin): risk of severe respiratory depression
MHRA Drug Safety Update (Apr 2022): Pregabalin (Lyrica): findings of safety study on risks during pregnancy
MHRA Drug Safety Update (Feb 2021): Pregabalin (Lyrica): reports of severe respiratory depression
MHRA Drug Safety Update (June 2024): Topiramate (Topamax): introduction of new safety measures, including a Pregnancy Prevention Programme
MHRA Drug Safety Update (Nov 2017): Antiepileptic drugs: updated advice on switching between different manufacturers’ products
MHRA Drug Safety Update (Nov 2017): Antiepileptic drugs: updated advice on switching between different manufacturers’ products
NENC Palliative and End of Life Care Symptom Control Guidelines
NICE CG137: The epilepsies: the diagnosis and management of the epilepsies in adults and children in primary and secondary care
NICE NG217: Epilepsies in children, young people and adults
NICE NG62: Cerebral palsy in under 25s: assessment and management
NICE TA232: Retigabine for the adjunctive treatment of adults with partial onset seizures in epilepsy with and without secondary generalisation
NICE TA614: Cannabidiol with clobazam for treating seizures associated with Dravet syndrome
NICE TA615: Cannabidiol with clobazam for treating seizures associated with Lennox–Gastaut syndrome
NICE TA753: Cenobamate for treating focal onset seizures in epilepsy
NICE TA808: Fenfluramine for treating seizures associated with Dravet syndrome
NICE TA873: Cannabidiol for treating seizures caused by tuberous sclerosis complex
North of Tyne, Gateshead and North Cumbria - Vigabatrin Shared Care Guideline
NTAG - Perampanel (Fycompa®) for epilepsy
TEWV - Medicines Optimisation – Interactive Guide
TEWV Guidelines
TEWV Safe Transfer of Prescribing Guidance
Valproate medicines: Pregnancy Prevention Programme materials
Key
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