North East and North Cumbria
ICS Formulary
 
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5 Infections
05-01-04 Aminoglycosides

Amikacin
Formulary
  • Restricted for use on microbiology/infectious diseases advice, or as agreed in Trust Guidelines.
  • Approved for the treatment of non-tuberculous mycobacterial pulmonary diseases caused by Mycobacterium Avium Complex (MAC) that is refractory to current treatment options (adults and post pubescent children) in line with NHSE Specialised Commissioning Policy 
Link  Clinical commissioning policy: Nebulised liposomal amikacin for the treatment of non-tuberculous mycobacterial pulmonary disease caused by mycobacterium avium complex refractory to current treatment options (adults and post pubescent children)

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Gentamicin
Formulary
  • 80mg in 2ml & 20mg in 2ml IV/IM injections
  • 5mg in 1ml intrathecal injection
  • bone cement & beads (for use in orthopaedic surgery) unlicensedunlicensed.

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Neomycin
Formulary
  • 500mg tablets
  • 1g in 10ml syrup unlicensedunlicensed.

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Tobramycin
Formulary
  • Restricted for use on microbiology/infectious diseases advice, or as agreed in Trust Guidelines.
    • 80mg in 2ml & 240mg in 6ml injections.
  • Inhaled preparations to be used for treatment of Cystic Fibrosis in accordance with NHS England Commissioning Policy/NICE Guidance.
    • 300mg/4ml nebuliser solution ampoules (Bramitob®);
    • 300mg/5ml nebuliser solution ampoules (Tobi®);
    • 170mg/1.7ml nebuliser solution ampoules (Vantobra®);
    • 28mg inhalation powder capsules (Tobi® Podhaler)  
Link  Clinical Commissioning Policy: Inhaled Therapy for Adults and Children with Cystic Fibrosis
Link  TA276:Colistimethate sodium and tobramycin dry powders for inhalation for treating pseudomonas lung infection in cystic fibrosis

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Gentamicin
Formulary
  • Approved for
    • For long term therapy in non-cystic fibrosis bronchiectasis usually in patients having > 3 exacerbations per annum with an organism identified as being sensitive to gentamicin.
    • Nebulised therapy for patients on assisted ventilation, patients with tracheostomies and those with persistant bacterial bronchitis 
Link  North of Tyne, Gateshead and North Cumbria - Nebulised Gentamicin Information for Primary Care (March 2023)

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Spectinomycin
Formulary
  • Only approved for the treatment of gonorrhoea in adults.

 


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