North East and North Cumbria
ICS Formulary
 
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6 Endocrine system
06-01-05 Diabetic neuropathy

Duloxetine 30mg and 60mg capsules
First Choice

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Amitriptyline
Second Choice

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Gabapentin
Third Choice
  • Also approved for hospital use as an adjunct to other treatment in
    the management of peri/post-operative pain. Red
  • GPs should not be asked to prescribe gabapentin for this unlicensedunlicensed indication.
Link  MHRA Drug Safety Alert (Oct 2017): Gabapentin (Neurontin): risk of severe respiratory depression

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Pregabalin
Formulary
Link  MHRA Drug Safety Update (Apr 2022): Pregabalin (Lyrica): findings of safety study on risks during pregnancy
Link  MHRA Drug Safety Update (Feb 2021): Pregabalin (Lyrica): reports of severe respiratory depression

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Tramadol
Formulary
  • 50mg capsules, 50mg dispersible tablets & 100mg/2ml injection
Link  MHRA Drug Safety Update (June 2024): Warfarin: be alert to the risk of drug interactions with tramadol

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