North East and North Cumbria
ICS Formulary
 
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6 Endocrine system
06-05-01 Anterior pituitary hormones

Tetracosactide Synacthen®
Formulary
  • Approved formulations include:
    • 250microgram in 1ml injection;
    • 1mg in 1ml depot injection. 


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Choriogonadotropin Alfa Ovitrelle®
Formulary

  •   Fertility treatment Red Traffic Light

  •   Hypogonadism Green Traffic Light


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Lutropin Alfa
Formulary

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Menotrophin (75 units FSH & 75 units LH activity) injection
Formulary

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Pegvisomant Somavert®
Formulary

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Somatrogon Ngenla®
Formulary

24mg and 60mg solution for injection in pre-filled pen

Link  NICE TA863: Somatrogon for treating growth disturbance in children and young people aged 3 years and over

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Somatropin (children)
Formulary
  • First line
  • Omnitrope® 5-mg (15-unit) vial (powder with diluent) for use with Omnitrope Pen L® device, 3.3 mg (10 units)/ml, 1.5 ml (5-mg, 15-unit) cartridge & 6.7 mg (20 units)/ml, 1.5 ml (10-mg, 30-unit) cartridge - for use with Omnitrope Pen 5® & Omnitrope Pen 10® devices respectively. 
  • Note: Omnitrope is the least expensive formulation of somatropin and should be used in all de novo paediatric patients where possible. 
  • Second line 
  • Norditropin SimpleXx® 1.5ml cartridges for use in Nordipen® devices - 5mg (15 units), 10mg (30 units) and 15mg (45 units). Note: norditropin is the second least expensive alternative formulation for patients who cannot tolerate omnitrope. 
  • Saizen® 8mg vials (powder with diluent), Saizen® 5.83 mg/ml solution for injection (6mg cartridges), 8 mg/ml solution for injection (12mg and 20mg cartridges) - for use in EasyPod® device (to be used in patients with compliance issues).
  • Third line
  • Genotropin Miniquick® syringes - 0.2mg (0.6 units) 0.8mg (2.4 units) 1.4mg (4.2 units), 0.4mg (1.2 units) 1mg (3 units) 1.6mg (4.8 units) 0.6mg (1.8 units), 1.2mg (3.6 units) 2mg (6 units). To be used for patients when travelling.
  • Zomacton® (needle free presentation) 12 unit (4mg) injection; 1st line: 75% to 85% of total mg usage; 2nd line: 15% to 25% of total mg usage; 3rd line: up to 5% of total mg usage.
Link  NICE TA188: Human growth hormone (somatropin) for the treatment of growth failure in children

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Somatropin - adults
Formulary
  • Genotropin® cartridges for use in Genotropin pens - 16 unit (5.3mg) & 36 unit (12mg) in 1ml. 
  • Genotropin Miniquick® syringes - 0.2mg (0.6 units), 0.8mg (2.4 units), 1.4mg (4.2 units) 0.4mg (1.2 units) 1mg (3 units) 1.6mg (4.8 units) 0.6mg (1.8 units) 1.2mg (3.6 units) 2mg (6 units) - to be used for patients when travelling.
Link  NICE TA64: Human growth hormone (somatropin) in adults with growth hormone deficiency

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Follitropin Alfa
Formulary

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