North East and North Cumbria
ICS Formulary
 
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8 Malignant disease and immunosuppression
08-01 Drugs for cytotoxic-induced side-effects

Calcium Folinate
Formulary
  • Approved for methotrexate-induced mucositis and myelosuppression. The following formulations are approved:
    • 15mg tablets.
    • 3mg, 15mg, 30mg, and 300mg injections
    • A calcium folinate 1mg per ml mouthwash can be prepared if needed.unlicensedunlicensed

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Dexrazoxane  Savene®
Formulary
  • For use in line with NECN extravasation.

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Mesna
Formulary
  • Approved formulations include 1gram in 10ml injection and 400mg tablets.

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Glucarpidase
Formulary
  • Approved for the urgent treatment of methotrexate-induced renal
    dysfunction.
Link  NHS England: Glucarpidase for the urgent treatment of methotrexateinduced renal dysfunction

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