North East and North Cumbria
ICS Formulary
 
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8 Malignant disease and immunosuppression
08-02-04 Lenalidomide, pomalidomide, and thalidomide

Lenalidomide 
Formulary
  • Approved for multiple myeloma in line with NICE - approved for myelodysplastic syndrome with 5q deletion in line with NICE. 
  • Approved in combination with dexamethasone for previously untreated multiple myeloma in line with NICE 
  • Approved in combination with dexamethasone for multiple myeloma after one treatment with bortezomib
  • Approved for maintenance treatment after an autologous stem cell transplant for newly diagnosed multiple myeloma in adults in line with NICE
  • Approved with rituximab for previously treated follicular lymphoma (grade 1 to 3A) in adults in line with NICE

 



Link  Letter sent to healthcare professionals (Nov 2016): lenalidomide (Revlimid▼): new advice about viral reactivation
Link  MHRA Drug Safety Update (Feb 2011): Lenalidomide: risk of thrombosis and thromboembolism
Link  MHRA Drug Safety Update (Jan 2013): Lenalidomide (Revlimid): risk of serious hepatic adverse drug reactions
Link  MHRA Drug Safety Update (May 2020): Immunomodulatory drugs and pregnancy prevention: temporary advice for management during coronavirus (COVID-19)
Link  MHRA Drug Safety Update (Nov 2011): Lenalidomide (Revlimid▼): update on risk of second primary malignancy
Link  NICE TA171: Lenalidomide for the treatment of multiple myeloma in people who have received at least 2 prior therapies
Link  NICE TA27: Lenalidomide with rituximab for previously treated follicular lymphoma
Link  NICE TA322: Lenalidomide for treating myelodysplastic syndromes associated with an isolated deletion 5q cytogenetic abnormality
Link  NICE TA586: Lenalidomide plus dexamethasone for multiple myeloma after 1 treatment with bortezomib
Link  NICE TA587: Lenalidomide plus dexamethasone for previously untreated multiple myeloma
Link  NICE TA680: Lenalidomide maintenance treatment after an autologous stem cell transplant for newly diagnosed multiple myeloma

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Pomalidomide Imnovid®
Formulary
  • For the treatment of multiple myeloma previously treated with lenalidomide and bortezomib in line with NICE and NHS Commissioning Policy
Link  NICE TA427: Pomalidomide for multiple myeloma previously treated with lenalidomide and bortezomib

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Thalidomide
Formulary
  • Approved in combination with an alkylating agent and a corticosteroid for the first-line treatment of multiple myeloma in line with NICE. 
  • Approved for the treatment of bleeding from bowel angiodysplasia in patients with an inherited/acquired bleeding disorder on specialist advice only.
  • Approved for the treatment of severe epistaxis as a result of hereditary haemorrhagic telangiectasia (HHT) who have failed all other treatments.
Link  Letter sent to healthcare professionals in June 2016: Thalidomide Celgene®: New important advice regarding viral reactivation and pulmonary hypertension
Link  MHRA Drug Safety Update (December 2015): Thalidomide: reduced starting dose in patients older than age 75 years
Link  MHRA Drug Safety Update (July 2011): Thalidomide: risk of arterial and venous thromboembolism
Link  MHRA Drug Safety Update (May 2013): Thalidomide: risk of second primary malignancies
Link  MHRA Drug Safety Update (May 2020): Immunomodulatory drugs and pregnancy prevention: temporary advice for management during coronavirus (COVID-19)
Link  NICE TA228: Bortezomib and thalidomide for the first‑line treatment of multiple myeloma

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