North East and North Cumbria
ICS Formulary
ICS Formulary
8 Malignant disease and immunosuppression
08-01-05 Protein kinase inhibitors
| Afatinib |
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Formulary
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 NICE TA310: Afatinib for treating epidermal growth factor receptor mutation-positive locally advanced or metastatic non-small-cell lung cancer |
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| Axitinib Inlyta® |
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Formulary
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MHRA Drug Safety Update (July 2020): Systemically administered VEGF pathway inhibitors: risk of aneurysm and artery dissection NICE TA333: Axitinib for treating advanced renal cell carcinoma after failure of prior systemic treatment NICE TA645: Avelumab with axitinib for untreated advanced renal cell carcinoma |
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| Bosutinib Bosulif® |
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Formulary
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NICE TA401: Bosutinib for previously treated chronic myeloid leukaemia MHRA Drug Safety Update (May 2016): BCR-ABL tyrosine kinase inhibitors: risk of hepatitis B reactivation |
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| Brigatinib Alunbrig® |
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Formulary
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NICE TA571: Brigatinib for treating ALK-positive advanced non-small-cell lung cancer after crizotinib NICE TA670: Brigatinib for ALK-positive advanced non-small-cell lung cancer that has not been previously treated with an ALK inhibitor |
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| Cabozantinib Cometriq® |
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Formulary
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NICE TA463 Cabozantinib for previously treated advanced renal cell carcinoma NICE TA516: Cabozantinib for treating medullary thyroid cancer NICE TA542: Cabozantinib for untreated advanced renal cell carcinoma NICE TA849: Cabozantinib for previously treated advanced hepatocellular carcinoma NICE TA964: Cabozantinib with nivolumab for untreated advanced renal cell carcinoma MHRA Drug Safety Update (July 2020): Systemically administered VEGF pathway inhibitors: risk of aneurysm and artery dissection |
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| Ceritinib |
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Formulary
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NICE TA395: Ceritinib for previously treated anaplastic lymphoma kinase positive non-small-cell lung cancer NICE TA500: Ceritinib for untreated ALK-positive non-small-cell lung cancer |
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| Dasatinib Sprycel® |
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Formulary
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NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia MHRA Drug Safety Update (May 2016): BCR-ABL tyrosine kinase inhibitors: risk of hepatitis B reactivation |
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| Encorafenib Braftovi® |
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Formulary
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NICE TA562: Encorafenib with binimetinib for unresectable or metastatic BRAF V600 mutation-positive melanoma NICE TA668: Encorafenib plus cetuximab for previously treated BRAF V600E mutation-positive metastatic colorectal cancer |
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| Everolimus Afinitor®, Votubia® |
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Formulary
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 Clinical Commissioning Policy Statement: Everolimus (Votubia®) for treatment of angiomyolipomas associated with tuberous sclerosis Clinical Commissioning Policy: Everolimus for subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis complex NICE TA348: Everolimus for preventing organ rejection in liver transplantation NICE TA421: Everolimus with exemestane for treating advanced breast cancer after endocrine therapy NICE TA432: Everolimus (Afinitor) for advanced renal cell carcinoma after previous treatment NICE TA449 Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease NICE TA481: Immunosuppressive therapy for kidney transplant in adults NICE TA482: Immunosuppressive therapy for kidney transplant in children and young people NICE TA498: Lenvatinib with everolimus for previously treated advanced renal cell carcinoma |
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| Gefitinib |
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Formulary
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NICE TA192: Lung cancer (non-small-cell, first line) - gefitinib NICE TA374: Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy MHRA Drug Safety Update (May 2012): Epidermal growth factor receptor (EGFR) inhibitors: serious cases of keratitis and ulcerative keratitis |
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| Lapatinib Tyverb® |
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Formulary
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NICE TA257: in combination with an aromatase inhibitor for HER2 positive metastatic breast cancer |
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| Lenvatinib Kisplyx® |
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Formulary
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NICE TA 535: Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine NICE TA 551: Lenvatinib for untreated advanced hepatocellular carcinoma NICE TA498: Lenvatinib with everolimus for previously treated advanced renal cell carcinoma MHRA Drug Safety Update (July 2020): Systemically administered VEGF pathway inhibitors: risk of aneurysm and artery dissection |
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| Mobocertinib |
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Formulary
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NICE TA855: Mobocertinib for treating EGFR exon 20 insertion mutation-positive advanced non-small-cell lung cancer after platinum-based chemotherapy |
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| Nilotinib Tasigna® |
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Formulary
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NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia MHRA Drug Safety Update (May 2016): BCR-ABL tyrosine kinase inhibitors: risk of hepatitis B reactivation |
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| Nintedanib |
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Formulary
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NICE TA347: Recurrent non-small-cell lung cancer NICE TA379: Nintedanib for treating idiopathic pulmonary fibrosis NICE TA747 Nintedanib for treating progressive fibrosing interstitial lung diseases NICE TA864: Nintedanib for treating idiopathic pulmonary fibrosis when forced vital capacity is above 80% predicted MHRA Drug Safety Update (July 2020): Systemically administered VEGF pathway inhibitors: risk of aneurysm and artery dissection |
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| Pazopanib Votrient® |
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Formulary
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NICE TA215: Pazopanib in renal cell cancer MHRA Drug Safety Update (July 2020): Systemically administered VEGF pathway inhibitors: risk of aneurysm and artery dissection |
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| Pemigatinib Pemaryze® |
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Formulary
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NICE TA722: Pemigatinib for treating relapsed or refractory advanced cholangiocarcinoma with FGFR2 fusion or rearrangement |
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| Ponatinib Iclusig® |
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Formulary
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NICE TA451 Ponatinib for treating chronic myeloid leukaemia and acute lymphoblastic leukaemia MHRA Drug Safety Update (July 2020): Systemically administered VEGF pathway inhibitors: risk of aneurysm and artery dissection MHRA Drug Safety Update (October 2018): Ponatinib (Iclusig▼): reports of posterior reversible encephalopathy syndrome MHRA Drug Safety Update (April 2017): Ponatinib (Iclusig▼): risk of vascular occlusive events—updated advice on possible dose reduction MHRA Drug Safety Update (May 2016): BCR-ABL tyrosine kinase inhibitors: risk of hepatitis B reactivation |
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| Regorafenib Stivarga® |
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Formulary
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NICE TA 488: Regorafenib for previously treated unresectable or metastatic gastrointestinal stromal tumours NICE TA555: Regorafenib for previously treated advanced hepatocellular carcinoma NICE TA866: Regorafenib for previously treated metastatic colorectal cancer MHRA Drug Safety Update (July 2020): Systemically administered VEGF pathway inhibitors: risk of aneurysm and artery dissection |
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| Ruxolitinib |
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Formulary
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NICE TA386: Ruxolitinib for treating disease-related splenomegaly or symptoms in adults with myelofibrosis NICE TA921: Ruxolitinib for treating polycythaemia vera |
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| Sorafenib Nexavar® |
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Formulary
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NHS England Specialised Commissioning Policy: Sorafenib maintenance for adults with FLT3-internal tandem duplication (FLT3-ITD) acute myeloid leukaemia (AML) undergoing allogeneic haematopoietic stem cell transplantation (allo-HSCT) NICE TA 535: Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine NICE TA474 Sorafenib for treating advanced hepatocellular carcinoma MHRA Drug Safety Update (July 2020): Systemically administered VEGF pathway inhibitors: risk of aneurysm and artery dissection |
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| Sunitinib Sutent® |
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Formulary
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NICE TA169: Sunitinib for the first-line treatment of advanced and/or metastatic renal cell carcinoma NICE TA179: Sunitinib for the treatment of gastrointestinal stromal tumours NICE TA449 Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease MHRA Drug Safety Update (January 2011): Bevacizumab and sunitinib: risk of osteonecrosis of the jaw MHRA Drug Safety Update (July 2020): Systemically administered VEGF pathway inhibitors: risk of aneurysm and artery dissection |
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| Trametinib |
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Formulary
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NICE TA396: Trametinib in combination with dabrafenib for treating unresectable or metastatic melanoma NICE TA544: Dabrafenib with trametinib for adjuvant treatment of resected BRAF V600 mutation-positive melanoma MHRA Drug Safety Update (March 2016) Trametinib (Mekinist▼): risk of gastrointestinal perforation and colitis |
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| Tucatinib Tukysa® |
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Formulary
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NICE TA786: Tucatinib with trastuzumab and capecitabine for treating HER2-positive advanced breast cancer after 2 or more anti-HER2 therapies |
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| Vemurafenib |
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Formulary
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NICE TA269: Vemurafenib for treating malignant melanoma NICE TA414: Cobimetinib in combination with vemurafenib for treating unresectable or metastatic BRAF V600 mutation-positive melanoma |
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| Zanubrutinib Brukinsa® |
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Formulary
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NICE TA833: Zanubrutinib for treating Waldenstrom’s macroglobulinaemia |
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| Zanubrutinib Brukinsa® |
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Non Formulary
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NICE TA978: Zanubrutinib with obinutuzumab for treating relapsed or refractory B-cell follicular lymphoma after 2 or more treatments (terminated appraisal) |
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Links
- NICE TA378: Ramucirumab for treating advanced gastric cancer or gastro–oesophageal junction adenocarcinoma previously treated with chemotherapy
- Cancer Drug Fund List
- Clinical Commissioning Policy Statement: Everolimus (Votubia®) for treatment of angiomyolipomas associated with tuberous sclerosis
- Clinical Commissioning Policy: Everolimus for subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis complex
- MHRA Drug Safety Update (April 2016): Aflibercept (Zaltrap▼): minimising the risk of osteonecrosis of the jaw
- MHRA Drug Safety Update (April 2017): Ponatinib (Iclusig▼): risk of vascular occlusive events—updated advice on possible dose reduction
- MHRA Drug Safety Update (Aug 2019): Carfilzomib (Kyprolis▼): reminder of risk of potentially fatal cardiac events
- MHRA Drug Safety Update (Aug 2019): Daratumumab (Darzalex▼): risk of reactivation of hepatitis B virus
- MHRA Drug Safety Update (August 2017): Ibrutinib (Imbruvica▼): reports of ventricular tachyarrhythmia; risk of hepatitis B reactivation and of opportunistic infections
- MHRA Drug Safety Update (Dec 2019): Carfilzomib (Kyprolis▼): risk of reactivation of hepatitis B virus
- MHRA Drug Safety Update (Dec 2021): Venetoclax (Venclyxto▼): updated recommendations on tumour lysis syndrome (TLS)
- MHRA Drug Safety Update (December 2014) Cabazitaxel (Jevtana▼): risk of medication error resulting in overdose
- MHRA Drug Safety Update (Jan 2019): Ipilimumab (Yervoy): reports of cytomegalovirus (CMV) gastrointestinal infection or reactivation
- MHRA Drug Safety Update (Jan 2022): Paclitaxel formulations (conventional and nab-paclitaxel): caution required due to potential for medication error
- MHRA Drug Safety Update (Jan 2022): Paclitaxel formulations (conventional and nab-paclitaxel): caution required due to potential for medication error
- MHRA Drug Safety Update (January 2011): Bevacizumab and sunitinib: risk of osteonecrosis of the jaw
- MHRA Drug Safety Update (January 2011): Bevacizumab and sunitinib: risk of osteonecrosis of the jaw
- MHRA Drug Safety Update (July 2017): Nivolumab (Opdivo▼), pembrolizumab (Keytruda▼): reports of organ transplant rejection
- MHRA Drug Safety Update (July 2017): Nivolumab (Opdivo▼), pembrolizumab (Keytruda▼): reports of organ transplant rejection
- MHRA Drug Safety Update (July 2017): Nivolumab (Opdivo▼), pembrolizumab (Keytruda▼): reports of organ transplant rejection
- MHRA Drug Safety Update (July 2020): Systemically administered VEGF pathway inhibitors: risk of aneurysm and artery dissection
- MHRA Drug Safety Update (July 2020): Systemically administered VEGF pathway inhibitors: risk of aneurysm and artery dissection
- MHRA Drug Safety Update (July 2020): Systemically administered VEGF pathway inhibitors: risk of aneurysm and artery dissection
- MHRA Drug Safety Update (July 2020): Systemically administered VEGF pathway inhibitors: risk of aneurysm and artery dissection
- MHRA Drug Safety Update (July 2020): Systemically administered VEGF pathway inhibitors: risk of aneurysm and artery dissection
- MHRA Drug Safety Update (July 2020): Systemically administered VEGF pathway inhibitors: risk of aneurysm and artery dissection
- MHRA Drug Safety Update (July 2020): Systemically administered VEGF pathway inhibitors: risk of aneurysm and artery dissection
- MHRA Drug Safety Update (July 2020): Systemically administered VEGF pathway inhibitors: risk of aneurysm and artery dissection
- MHRA Drug Safety Update (July 2020): Systemically administered VEGF pathway inhibitors: risk of aneurysm and artery dissection
- MHRA Drug Safety Update (July 2020): Systemically administered VEGF pathway inhibitors: risk of aneurysm and artery dissection
- MHRA Drug Safety Update (July 2020): Systemically administered VEGF pathway inhibitors: risk of aneurysm and artery dissection
- MHRA Drug Safety Update (July 2020): Systemically administered VEGF pathway inhibitors: risk of aneurysm and artery dissection
- MHRA Drug Safety Update (June 2021): Atezolizumab (Tecentriq▼) and other immune-stimulatory anti-cancer drugs: risk of severe cutaneous adverse reactions (SCARs)
- MHRA Drug Safety Update (March 2016) Trametinib (Mekinist▼): risk of gastrointestinal perforation and colitis
- MHRA Drug Safety Update (May 2010): Panitumumab (Vectibix): serious hypersensitivity reactions
- MHRA Drug Safety Update (May 2012): Epidermal growth factor receptor (EGFR) inhibitors: serious cases of keratitis and ulcerative keratitis
- MHRA Drug Safety Update (May 2016): BCR-ABL tyrosine kinase inhibitors: risk of hepatitis B reactivation
- MHRA Drug Safety Update (May 2016): BCR-ABL tyrosine kinase inhibitors: risk of hepatitis B reactivation
- MHRA Drug Safety Update (May 2016): BCR-ABL tyrosine kinase inhibitors: risk of hepatitis B reactivation
- MHRA Drug Safety Update (May 2016): BCR-ABL tyrosine kinase inhibitors: risk of hepatitis B reactivation
- MHRA Drug Safety Update (May 2016): BCR-ABL tyrosine kinase inhibitors: risk of hepatitis B reactivation
- MHRA Drug Safety Update (May 2016): Idelalisib (Zydelig▼): interim measures following signal of serious infection and deaths related to infection found in clinical trials.
- MHRA Drug Safety Update (Nov 2015): Crizotinib (Xalkori▼): risk of cardiac failure
- MHRA Drug Safety Update (Oct 2019): Nivolumab (Opdivo): reports of cytomegalovirus (CMV) gastrointestinal infection or reactivation
- MHRA Drug Safety Update (Oct 2020): Niraparib (Zejula▼): reports of severe hypertension and posterior reversible encephalopathy syndrome (PRES), particularly in early treatment
- MHRA Drug Safety Update (October 2018): Ponatinib (Iclusig▼): reports of posterior reversible encephalopathy syndrome
- MHRA Drug Safety Update (Sep 2022) Rucaparib (Rubraca▼): withdrawal of third-line treatment indication
- MHRA Drug Safety Update (September 2012): Panitumumab (Vectibix): risk of necrotising fasciitis
- MHRA Drug Safety Update (September 2013): Panitumumab: treatment of metastatic colorectal cancer
- MHRA Drug Safety Update (September 2016): Idelalisib (Zydelig▼): updated indications and advice on minimising the risk of infection
- MHRA Drug Safety Updates (July 2020) Systemically administered VEGF pathway inhibitors: risk of aneurysm and artery dissection
- MHRA Drug Safety Update (Feb 2014): Cetuximab: new safety information available
- MHRA Drug Safety Update (May 2012): Epidermal growth factor receptor (EGFR) inhibitors: serious cases of keratitis and ulcerative keratitis
- MHRA Drug Safety Update (May 2012): Epidermal growth factor receptor (EGFR) inhibitors: serious cases of keratitis and ulcerative keratitis
- MHRA Drug Safety Update (May 2012): Epidermal growth factor receptor (EGFR) inhibitors: serious cases of keratitis and ulcerative keratitis
- NHS England Specialised Commissioning Policy: Sorafenib maintenance for adults with FLT3-internal tandem duplication (FLT3-ITD) acute myeloid leukaemia (AML) undergoing allogeneic haematopoietic stem cell transplantation (allo-HSCT)
- NHS England: Glucarpidase for the urgent treatment of methotrexateinduced renal dysfunction
- NICE HST20 Selumetinib for treating symptomatic and inoperable plexiform neurofibromas associated with type 1 neurofibromatosis in children aged 3 and over
- NICE HST20: Selumetinib for treating symptomatic and inoperable plexiform neurofibromas associated with type 1 neurofibromatosis in children aged 3 and over
- NICE NG101: Early and locally advanced breast cancer: diagnosis and management
- NICE NG101: Early and locally advanced breast cancer: diagnosis and management
- NICE TA 488: Regorafenib for previously treated unresectable or metastatic gastrointestinal stromal tumours
- NICE TA 535: Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine
- NICE TA 535: Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine
- NICE TA 538: Dinutuximab beta for treating neuroblastoma
- NICE TA 551: Lenvatinib for untreated advanced hepatocellular carcinoma
- NICE TA100: Capecitabine and oxaliplatin in the adjuvant treatment of stage III (Dukes’ C) colon cancer
- NICE TA101: Docetaxel for the treatment of hormone-refractory metastatic prostate cancer
- NICE TA121: Glioma (newly diagnosed and high grade)
- NICE TA129: Multiple myeloma - bortezomib
- NICE TA145: Cetuximab for the treatment of locally advanced squamous cell cancer of the head and neck
- NICE TA169: Sunitinib for the first-line treatment of advanced and/or metastatic renal cell carcinoma
- NICE TA179: Sunitinib for the treatment of gastrointestinal stromal tumours
- NICE TA183: Topotecan for the treatment of recurrent and stage IVB cervical cancer
- NICE TA184: Topotecan for the treatment of relapsed small-cell lung cancer
- NICE TA185: Soft tissue sarcoma - trabectedin
- NICE TA192: Lung cancer (non-small-cell, first line) - gefitinib
- NICE TA208: Gastric cancer (HER2-positive metastatic) - trastuzumab
- NICE TA209: Imatinib for the treatment of unresectable and/or metastatic gastrointestinal stromal tumours
- NICE TA215: Pazopanib in renal cell cancer
- NICE TA227: Erlotinib monotherapy for maintenance treatment of non-small-cell lung cancer
- NICE TA228: Bortezomib and thalidomide for the first‑line treatment of multiple myeloma
- NICE TA23: Guidance on the use of temozolomide for the treatment of recurrent malignant glioma (brain cancer)
- NICE TA242: Cetuximab for the treatment of metastatic colorectal cancer after first-line chemotherapy: monotherapy or combination chemotherapy
- NICE TA257: in combination with an aromatase inhibitor for HER2 positive metastatic breast cancer
- NICE TA257: in combination with an aromatase inhibitor for HER2 positive metastatic breast cancer
- NICE TA258: Erlotinib for the first-line treatment of locally advanced or metastatic EGFR-TK mutation-positive non-small-cell lung cancer
- NICE TA268: Ipilimumab for previously treated advanced (unresectable or metastatic) melanoma
- NICE TA269: Vemurafenib for treating malignant melanoma
- NICE TA284:Bevacizumab in combination with paclitaxel and carboplatin for first-line treatment of advanced ovarian cancer
- NICE TA285: Ovarian, fallopian tube and primary peritoneal cancer (recurrent advanced, platinum-sensitive or partially platinum-sensitive) - bevacizumab
- NICE TA307: Aflibercept in combination with irinotecan and fluorouracil-based therapy for treating metastatic colorectal cancer that has progressed following prior oxaliplatin-based chemotherapy
- NICE TA310: Afatinib for treating epidermal growth factor receptor mutation-positive locally advanced or metastatic non-small-cell lung cancer
- NICE TA311: Bortezomib for induction therapy in multiple myeloma before high-dose chemotherapy and autologous stem cell transplantation
- NICE TA319: Ipilimumab for previously untreated advanced (unresectable or metastatic) melanoma
- NICE TA321: Dabrafenib for treating unresectable or metastatic BRAF V600 mutation‑positive melanoma
- NICE TA326: Imatinib for the adjuvant treatment of gastrointestinal stromal tumours
- NICE TA333: Axitinib for treating advanced renal cell carcinoma after failure of prior systemic treatment
- NICE TA34: Breast cancer - trastuzumab
- NICE TA347: Recurrent non-small-cell lung cancer
- NICE TA348: Everolimus for preventing organ rejection in liver transplantation
- NICE TA353: Bevacizumab for treating relapsed, platinum‑resistant epithelial ovarian, fallopian tube or primary peritoneal cancer (terminated appraisal)
- NICE TA357: Pembrolizumab for treating advanced melanoma after disease progression with ipilimumab
- NICE TA357: Pembrolizumab for treating advanced melanoma after disease progression with ipilimumab
- NICE TA359: Chronic lymphocytic leukaemia - Idelalisib
- NICE TA366: Pembrolizumab for advanced melanoma not previously treated with ipilimumab
- NICE TA366: Pembrolizumab for advanced melanoma not previously treated with ipilimumab
- NICE TA370: Bortezomib for previously untreated mantle cell lymphoma
- NICE TA374: Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy
- NICE TA374: Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy
- NICE TA379: Nintedanib for treating idiopathic pulmonary fibrosis
- NICE TA380: Panobinostat for treating multiple myeloma after at least 2 previous treatments
- NICE TA384: Nivolumab for treating advanced (unresectable or metastatic) melanoma
- NICE TA386: Ruxolitinib for treating disease-related splenomegaly or symptoms in adults with myelofibrosis
- NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
- NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
- NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
- NICE TA391: Cabazitaxel for hormone-relapsed metastatic prostate cancer treated with docetaxel
- NICE TA395: Ceritinib for previously treated anaplastic lymphoma kinase positive non-small-cell lung cancer
- NICE TA396: Trametinib in combination with dabrafenib for treating unresectable or metastatic melanoma
- NICE TA396: Trametinib in combination with dabrafenib for treating unresectable or metastatic melanoma
- NICE TA400: Nivolumab in combination with ipilimumab for treating advanced melanoma
- NICE TA400: Nivolumab in combination with ipilimumab for treating advanced melanoma
- NICE TA401: Bosutinib for previously treated chronic myeloid leukaemia
- NICE TA403: Ramucirumab for previously treated locally advanced or metastatic non-small-cell lung cancer
- NICE TA406: Crizotinib for untreated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer
- NICE TA408: Pegaspargase for treating acute lymphoblastic leukaemia
- NICE TA410: Talimogene laherparepvec for treating unresectable metastatic melanoma
- NICE TA411: Necitumumab for untreated advanced or metastatic squamous non-small-cell lung cancer
- NICE TA414: Cobimetinib in combination with vemurafenib for treating unresectable or metastatic BRAF V600 mutation-positive melanoma
- NICE TA417: Nivolumab for previously treated advanced renal cell carcinoma
- NICE TA421: Everolimus with exemestane for treating advanced breast cancer after endocrine therapy
- NICE TA422: Crizotinib for previously treated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer
- NICE TA423: Eribulin for treating locally advanced or metastatic breast cancer after 2 or more chemotherapy regimens
- NICE TA424: Pertuzumab for the neoadjuvant treatment of HER2-positive breast cancer
- NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
- NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
- NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
- NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
- NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
- NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
- NICE TA427: Pomalidomide for multiple myeloma previously treated with lenalidomide and bortezomib
- NICE TA428: Pembrolizumab for treating PD-L1-positive non-small-cell lung cancer after chemotherapy
- NICE TA428: Pembrolizumab for treating PD-L1-positive non-small-cell lung cancer after chemotherapy
- NICE TA429: Ibrutinib for previously treated chronic lymphocytic leukaemia and untreated chronic lymphocytic leukaemia with 17p deletion or TP53 mutation
- NICE TA432: Everolimus (Afinitor) for advanced renal cell carcinoma after previous treatment
- NICE TA439 Cetuximab and panitumumab for previously untreated metastatic colorectal cancer
- NICE TA439 Cetuximab and panitumumab for previously untreated metastatic colorectal cancer
- NICE TA449 Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease
- NICE TA449 Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease
- NICE TA451 Ponatinib for treating chronic myeloid leukaemia and acute lymphoblastic leukaemia
- NICE TA458 Trastuzumab emtansine for treating HER2-positive advanced breast cancer after trastuzumab and a taxane
- NICE TA462 Nivolumab for treating relapsed or refractory classical Hodgkin lymphoma
- NICE TA463 Cabozantinib for previously treated advanced renal cell carcinoma
- NICE TA473 Cetuximab for treating recurrent or metastatic squamous cell cancer of the head and neck (oral cavity)
- NICE TA474 Sorafenib for treating advanced hepatocellular carcinoma
- NICE TA476 Paclitaxel as albumin-bound nanoparticles with gemcitabine for untreated metastatic pancreatic cancer
- NICE TA478 Brentuximab vedotin for treating relapsed or refractory systemic anaplastic large cell lymphoma
- NICE TA481: Immunosuppressive therapy for kidney transplant in adults
- NICE TA482: Immunosuppressive therapy for kidney transplant in children and young people
- NICE TA498: Lenvatinib with everolimus for previously treated advanced renal cell carcinoma
- NICE TA498: Lenvatinib with everolimus for previously treated advanced renal cell carcinoma
- NICE TA500: Ceritinib for untreated ALK-positive non-small-cell lung cancer
- NICE TA502: Ibrutinib for treating relapsed or refractory mantle cell lymphoma
- NICE TA509: Pertuzumab with trastuzumab and docetaxel for treating HER2-positive breast cancer
- NICE TA512: Tivozanib for treating advanced renal cell carcinoma
- NICE TA516: Cabozantinib for treating medullary thyroid cancer
- NICE TA520: Atezolizumab for treating locally advanced or metastatic non-small-cell lung cancer after chemotherapy
- NICE TA523 Midostaurin for untreated acute myeloid leukaemia
- NICE TA524 Brentuximab vedotin for treating CD30-positive Hodgkin lymphoma
- NICE TA525: Atezolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapy
- NICE TA526: Arsenic trioxide for treating acute promyelocytic leukaemia
- NICE TA529: Crizotinib for treating ROS1-positive advanced non-small-cell lung cancer
- NICE TA530: Nivolumab for treating locally advanced unresectable or metastatic urothelial cancer after platinum-containing chemotherapy
- NICE TA531: Pembrolizumab for untreated PD-L1-positive metastatic non-small-cell lung cancer
- NICE TA531: Pembrolizumab for untreated PD-L1-positive metastatic non-small-cell lung cancer
- NICE TA536: Alectinib for untreated ALK-positive advanced non-small-cell lung cancer
- NICE TA539: Lutetium (177Lu) oxodotreotide for treating unresectable or metastatic neuroendocrine tumours
- NICE TA541: Inotuzumab ozogamicin for treating relapsed or refractory B-cell acute lymphoblastic leukaemia
- NICE TA542: Cabozantinib for untreated advanced renal cell carcinoma
- NICE TA544: Dabrafenib with trametinib for adjuvant treatment of resected BRAF V600 mutation-positive melanoma
- NICE TA544: Dabrafenib with trametinib for adjuvant treatment of resected BRAF V600 mutation-positive melanoma
- NICE TA545: Gemtuzumab ozogamicin for untreated acute myeloid leukaemia
- NICE TA55: Guidance on the use of paclitaxel in the treatment of ovarian cancer
- NICE TA555: Regorafenib for previously treated advanced hepatocellular carcinoma
- NICE TA561: Venetoclax with rituximab for previously treated chronic lymphocytic leukaemia
- NICE TA562: Encorafenib with binimetinib for unresectable or metastatic BRAF V600 mutation-positive melanoma
- NICE TA569: Pertuzumab for adjuvant treatment of HER2-positive early stage breast cancer
- NICE TA571: Brigatinib for treating ALK-positive advanced non-small-cell lung cancer after crizotinib
- NICE TA577: Brentuximab vedotin for treating CD30-positive cutaneous T-cell lymphoma
- NICE TA584: Atezolizumab in combination for treating metastatic non-squamous non-small-cell lung cancer
- NICE TA595: Dacomitinib for untreated EGFR mutation-positive non-small-cell lung cancer
- NICE TA612: Neratinib for extended adjuvant treatment of hormone receptor-positive, HER2-positive early stage breast cancer after adjuvant trastuzumab
- NICE TA628: Lorlatinib for previously treated ALK-positive advanced non-small-cell lung cancer
- NICE TA630: Larotrectinib for treating NTRK fusion-positive solid tumours
- NICE TA632: Trastuzumab emtansine for adjuvant treatment of HER2-positive early breast cancer
- NICE TA638: Atezolizumab with carboplatin and etoposide for untreated extensive-stage small-cell lung cancer
- NICE TA639: Atezolizumab with nab-paclitaxel for untreated PD-L1-positive, locally advanced or metastatic, triple-negative breast cancer
- NICE TA641: Brentuximab vedotin in combination for untreated systemic anaplastic large cell lymphoma
- NICE TA642: Gilteritinib for treating relapsed or refractory acute myeloid leukaemia
- NICE TA643: Entrectinib for treating ROS1-positive advanced non-small-cell lung cancer
- NICE TA644 Entrectinib for treating NTRK fusion-positive solid tumours
- NICE TA645: Avelumab with axitinib for untreated advanced renal cell carcinoma
- NICE TA649: Polatuzumab vedotin with rituximab and bendamustine for treating relapsed or refractory diffuse large B-cell lymphoma
- NICE TA655: Nivolumab for advanced squamous non-small-cell lung cancer after chemotherapy
- NICE TA657: Carfilzomib for previously treated multiple myeloma (COVID-19)
- NICE TA658: Isatuximab with pomalidomide and dexamethasone for treating relapsed and refractory multiple myeloma
- NICE TA661: Pembrolizumab for untreated metastatic or unresectable recurrent head and neck squamous cell carcinoma
- NICE TA661: Pembrolizumab for untreated metastatic or unresectable recurrent head and neck squamous cell carcinoma
- NICE TA663 Venetoclax with obinutuzumab for untreated chronic lymphocytic leukaemia
- NICE TA666: Atezolizumab with bevacizumab for treating advanced or unresectable hepatocellular carcinoma
- NICE TA668: Encorafenib plus cetuximab for previously treated BRAF V600E mutation-positive metastatic colorectal cancer
- NICE TA670: Brigatinib for ALK-positive advanced non-small-cell lung cancer that has not been previously treated with an ALK inhibitor
- NICE TA673: Niraparib for maintenance treatment of advanced ovarian, fallopian tube and peritoneal cancer after response to first-line platinum-based chemotherapy
- NICE TA683: Pembrolizumab with pemetrexed and platinum chemotherapy for untreated, metastatic, non-squamous non-small-cell lung cancer
- NICE TA683: Pembrolizumab with pemetrexed and platinum chemotherapy for untreated, metastatic, non-squamous non-small-cell lung cancer
- NICE TA684: Nivolumab for adjuvant treatment of completely resected melanoma with lymph node involvement or metastatic disease
- NICE TA689: Acalabrutinib for treating chronic lymphocytic leukaemia
- NICE TA692: Pembrolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapy
- NICE TA692: Pembrolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapy
- NICE TA695: Carfilzomib with dexamethasone and lenalidomide for previously treated multiple myeloma
- NICE TA70: Guidance on the use of imatinib for chronic myeloid leukaemia
- NICE TA704: Trastuzumab deruxtecan for treating HER2-positive unresectable or metastatic breast cancer after 2 or more anti-HER2 therapies
- NICE TA705: Atezolizumab monotherapy for untreated advanced non-small-cell lung cancer
- NICE TA707: Nivolumab for previously treated unresectable advanced or recurrent oesophageal cancer
- NICE TA709: Pembrolizumab for untreated metastatic colorectal cancer with high microsatellite instability or mismatch repair deficiency
- NICE TA709: Pembrolizumab for untreated metastatic colorectal cancer with high microsatellite instability or mismatch repair deficiency
- NICE TA713: Nivolumab for advanced non-squamous non-small-cell lung cancer after chemotherapy
- NICE TA716: Nivolumab with ipilimumab for previously treated metastatic colorectal cancer with high microsatellite instability or mismatch repair deficiency
- NICE TA722: Pemigatinib for treating relapsed or refractory advanced cholangiocarcinoma with FGFR2 fusion or rearrangement
- NICE TA724: Nivolumab with ipilimumab and chemotherapy for untreated metastatic non-small- cell lung cancer
- NICE TA728: Midostaurin for treating advanced systemic mastocytosis
- NICE TA736: Nivolumab for treating recurrent or metastatic squamous cell carcinoma of the head and neck after platinum-based chemotherapy
- NICE TA737: Pembrolizumab with platinum- and fluoropyrimidine-based chemotherapy for untreated advanced oesophageal and gastro-oesophageal junction cancer
- NICE TA737: Pembrolizumab with platinum- and fluoropyrimidine-based chemotherapy for untreated advanced oesophageal and gastro-oesophageal junction cancer
- NICE TA739: Atezolizumab for untreated PD-L1-positive advanced urothelial cancer when cisplatin is unsuitable
- NICE TA742: Selpercatinib for treating advanced thyroid cancer with RET alterations
- NICE TA743: Crizanlizumab for preventing sickle cell crises in sickle cell disease
- NICE TA746: Nivolumab for adjuvant treatment of resected oesophageal or gastro-oesophageal junction cancer
- NICE TA747 Nintedanib for treating progressive fibrosing interstitial lung diseases
- NICE TA754: Mogamulizumab for previously treated mycosis fungoides and Sézary syndrome
- NICE TA760: Selpercatinib for previously treated RET fusion-positive advanced non-small-cell lung cancer
- NICE TA763: Daratumumab in combination for untreated multiple myeloma when a stem cell transplant is suitable
- NICE TA765: Venetoclax with azacitidine for untreated acute myeloid leukaemia when intensive chemotherapy is unsuitable
- NICE TA766: Pembrolizumab for adjuvant treatment of completely resected stage 3 melanoma
- NICE TA766: Pembrolizumab for adjuvant treatment of completely resected stage 3 melanoma
- NICE TA770: Pembrolizumab with carboplatin and paclitaxel for untreated metastatic squamous non-small-cell lung cancer
- NICE TA770: Pembrolizumab with carboplatin and paclitaxel for untreated metastatic squamous non-small-cell lung cancer
- NICE TA772: Pembrolizumab for treating relapsed or refractory classical Hodgkin lymphoma after stem cell transplant or at least 2 previous therapies
- NICE TA772: Pembrolizumab for treating relapsed or refractory classical Hodgkin lymphoma after stem cell transplant or at least 2 previous therapies
- NICE TA779: Dostarlimab for previously treated advanced or recurrent endometrial cancer with high microsatellite instability or mismatch repair deficiency
- NICE TA780: Nivolumab with ipilimumab for untreated advanced renal cell carcinoma
- NICE TA780: Nivolumab with ipilimumab for untreated advanced renal cell carcinoma
- NICE TA783: Daratumumab monotherapy for treating relapsed and refractory multiple myeloma
- NICE TA784: Niraparib for maintenance treatment of relapsed, platinum-sensitive ovarian, fallopian tube and peritoneal cancer
- NICE TA786: Tucatinib with trastuzumab and capecitabine for treating HER2-positive advanced breast cancer after 2 or more anti-HER2 therapies
- NICE TA787: Venetoclax with low dose cytarabine for untreated acute myeloid leukaemia when intensive chemotherapy is unsuitable
- NICE TA795: Ibrutinib for treating Waldenstrom’s macroglobulinaemia
- NICE TA796: Venetoclax for treating chronic lymphocytic leukaemia
- NICE TA798: Durvalumab for maintenance treatment of unresectable non-small-cell lung cancer after platinum-based chemoradiation
- NICE TA801: Pembrolizumab plus chemotherapy for untreated, triple-negative, locally recurrent unresectable or metastatic breast cancer
- NICE TA801: Pembrolizumab plus chemotherapy for untreated, triple-negative, locally recurrent unresectable or metastatic breast cancer
- NICE TA802: Cemiplimab for treating advanced cutaneous squamous cell carcinoma
- NICE TA809: Imlifidase for desensitisation treatment before kidney transplant in people with chronic kidney disease
- NICE TA813: Asciminib for treating chronic myeloid leukaemia after 2 or more tyrosine kinase inhibitors
- NICE TA817: Nivolumab for adjuvant treatment of invasive urothelial cancer at high risk of recurrence
- NICE TA818: Nivolumab with ipilimumab for untreated unresectable malignant pleural mesothelioma
- NICE TA819: Sacituzumab govitecan for treating unresectable triple-negative advanced breast cancer after 2 or more therapies
- NICE TA823: Atezolizumab for adjuvant treatment of resected non-small-cell lung cancer
- NICE TA830: Pembrolizumab for adjuvant treatment of renal cell carcinoma
- NICE TA830: Pembrolizumab for adjuvant treatment of renal cell carcinoma
- NICE TA833: Zanubrutinib for treating Waldenstrom’s macroglobulinaemia
- NICE TA835: Fostamatinib for treating refractory chronic immune thrombocytopenia
- NICE TA837: Pembrolizumab for adjuvant treatment of resected stage 2B or 2C melanoma
- NICE TA837: Pembrolizumab for adjuvant treatment of resected stage 2B or 2C melanoma
- NICE TA849: Cabozantinib for previously treated advanced hepatocellular carcinoma
- NICE TA855: Mobocertinib for treating EGFR exon 20 insertion mutation-positive advanced non-small-cell lung cancer after platinum-based chemotherapy
- NICE TA86: Imatinib for the treatment of unresectable and/or metastatic gastro-intestinal stromal tumours
- NICE TA862: HER2-positive unresectable or metastatic breast cancer after 1 or more anti-HER2 treatments
- NICE TA864: Nintedanib for treating idiopathic pulmonary fibrosis when forced vital capacity is above 80% predicted
- NICE TA865: Nivolumab with fluoropyrimidine- and platinum-based chemotherapy for untreated unresectable advanced, recurrent, or metastatic oesophageal squamous cell carcinoma
- NICE TA866: Regorafenib for previously treated metastatic colorectal cancer
- NICE TA870: Ixazomib with lenalidomide and dexamethasone for treating relapsed or refractory multiple myeloma
- NICE TA872: Axicabtagene ciloleucel for treating diffuse large B-cell lymphoma and primary mediastinal large B-cell lymphoma after 2 or more systemic therapies
- NICE TA874: Polatuzumab vedotin in combination for untreated diffuse large B-cell lymphoma
- NICE TA876: Nivolumab with chemotherapy for neoadjuvant treatment of resectable non-small-cell lung cancer
- NICE TA881: Ripretinib for treating advanced gastrointestinal stromal tumour after 3 or more treatments
- NICE TA883: Tafasitamab with lenalidomide for treating relapsed or refractory diffuse large B-cell lymphoma
- NICE TA885: Pembrolizumab plus chemotherapy with or without bevacizumab for persistent, recurrent or metastatic cervical cancer
- NICE TA885: Pembrolizumab plus chemotherapy with or without bevacizumab for persistent, recurrent or metastatic cervical cancer
- NICE TA886: Olaparib for adjuvant treatment of BRCA mutation-positive HER2-negative high-risk early breast cancer after chemotherapy
- NICE TA887: Olaparib for previously treated BRCA mutation-positive hormone-relapsed metastatic prostate cancer
- NICE TA891: Ibrutinib with venetoclax for untreated chronic lymphocytic leukaemia
- NICE TA892: Mosunetuzumab for treating relapsed or refractory follicular lymphoma
- NICE TA893: Brexucabtagene autoleucel for treating relapsed or refractory B-cell acute lymphoblastic leukaemia in people 26 years and over
- NICE TA895: Axicabtagene ciloleucel for treating relapsed or refractory diffuse large B-cell lymphoma after first-line chemoimmunotherapy
- NICE TA897: Daratumumab with bortezomib and dexamethasone for previously treated multiple myeloma
- NICE TA898: Dabrafenib plus trametinib for treating BRAF V600 mutation-positive advanced non-small-cell lung cancer
- NICE TA904: Pembrolizumab with lenvatinib for previously treated advanced or recurrent endometrial cancer
- NICE TA904: Pembrolizumab with lenvatinib for previously treated advanced or recurrent endometrial cancer
- NICE TA908: Olaparib for maintenance treatment of relapsed, platinum-sensitive ovarian, fallopian tube or peritoneal cancer after 2 or more courses of platinum-based chemotherapy
- NICE TA911: Selpercatinib for untreated RET fusion-positive advanced non-small-cell lung cancer
- NICE TA914: Pembrolizumab for previously treated endometrial, biliary, colorectal, gastric or small intestine cancer with high microsatellite instability or mismatch repair deficiency
- NICE TA914: Pembrolizumab for previously treated endometrial, biliary, colorectal, gastric or small intestine cancer with high microsatellite instability or mismatch repair deficiency
- NICE TA917: Daratumumab with lenalidomide and dexamethasone for untreated multiple myeloma when a stem cell transplant is unsuitable
- NICE TA921: Ruxolitinib for treating polycythaemia vera
- NICE TA927: Glofitamab for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic treatments
- NICE TA930: Lutetium-177 vipivotide tetraxetan for treating PSMA-positive hormone-relapsed metastatic prostate cancer after 2 or more treatments
- NICE TA931: Zanubrutinib for treating chronic lymphocytic leukaemia
- NICE TA933: Tisagenlecleucel for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic therapies (terminated appraisal)
- NICE TA936: Idecabtagene vicleucel for treating relapsed and refractory multiple myeloma after 3 or more treatments (terminated appraisal)
- NICE TA939: Pembrolizumab plus chemotherapy with or without bevacizumab for persistent, recurrent or metastatic cervical cancer
- NICE TA939: Pembrolizumab plus chemotherapy with or without bevacizumab for persistent, recurrent or metastatic cervical cancer
- NICE TA944: Durvalumab with gemcitabine and cisplatin for treating unresectable or advanced biliary tract cancer
- NICE TA946: Olaparib with bevacizumab for maintenance treatment of advanced high-grade epithelial ovarian, fallopian tube or primary peritoneal cancer
- NICE TA947: Loncastuximab tesirine for treating relapsed or refractory diffuse large B-cell lymphoma and high-grade B-cell lymphoma after 2 or more systemic treatments
- NICE TA948: Ivosidenib for treating advanced cholangiocarcinoma with an IDH1 R132 mutation after 1 or more systemic treatments
- NICE TA950: Nivolumab–relatlimab for untreated unresectable or metastatic melanoma in people 12 years and over
- NICE TA951: Olaparib with abiraterone for untreated hormone-relapsed metastatic prostate cancer
- NICE TA952: Talazoparib for treating HER2-negative advanced breast cancer with germline BRCA mutations
- NICE TA954: Epcoritamab for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic treatments
- NICE TA957: Momelotinib for treating myelofibrosis-related splenomegaly or symptoms
- NICE TA959: Daratumumab in combination for treating newly diagnosed systemic amyloid light-chain amyloidosis
- NICE TA962: Olaparib for maintenance treatment of BRCA mutation-positive advanced ovarian, fallopian tube or peritoneal cancer after response to first-line platinum-based chemotherapy
- NICE TA963: Dostarlimab with platinum-based chemotherapy for treating advanced or recurrent endometrial cancer with high microsatellite instability or mismatch repair deficiency
- NICE TA964: Cabozantinib with nivolumab for untreated advanced renal cell carcinoma
- NICE TA964: Cabozantinib with nivolumab for untreated advanced renal cell carcinoma
- NICE TA966: Pembrolizumab with gemcitabine and cisplatin for untreated advanced biliary tract cancer (terminated appraisal)
- NICE TA967: Pembrolizumab for treating relapsed or refractory classical Hodgkin lymphoma in people 3 years and over
- NICE TA967: Pembrolizumab for treating relapsed or refractory classical Hodgkin lymphoma in people 3 years and over
- NICE TA970: Selinexor with dexamethasone for treating relapsed or refractory multiple myeloma after 4 or more treatments
- NICE TA970: Selinexor with dexamethasone for treating relapsed or refractory multiple myeloma after 4 or more treatments
- NICE TA974: Selinexor with bortezomib and dexamethasone for previously treated multiple myeloma
- NICE TA974: Selinexor with bortezomib and dexamethasone for previously treated multiple myeloma
- NICE TA975: Tisagenlecleucel for treating relapsed or refractory B-cell acute lymphoblastic leukaemia in people 25 years and under
- NICE TA976: Trastuzumab deruxtecan for treating HER2-mutated advanced non-small-cell lung cancer after platinum-based chemotherapy (terminated appraisal)
- NICE TA977: Dabrafenib with trametinib for treating BRAF V600E mutation-positive glioma in children and young people aged 1 year and over
- NICE TA978: Zanubrutinib with obinutuzumab for treating relapsed or refractory B-cell follicular lymphoma after 2 or more treatments (terminated appraisal)
- NICE TA979: Ivosidenib with azacitidine for untreated acute myeloid leukaemia with an IDH1 R132 mutation
- NICE TA980: Nivolumab for adjuvant treatment of completely resected melanoma at high risk of recurrence in people 12 years and over (terminated appraisal)
- NICE TA983: Pembrolizumab with trastuzumab and chemotherapy for untreated locally advanced unresectable or metastatic HER2-positive gastric or gastro-oesophageal junction adenocarcinoma
- NICE TA987:Lisocabtagene maraleucel for treating relapsed or refractory aggressive B-cell non-Hodgkin lymphoma (terminated appraisal)
- Northern Cancer Alliance
- Northern England Clinical Networks Palliative and End of Life Care Guidelines
- Roche Healthcare Professional Letter (January 2016): Tarceva (erlotinib)
- TA992: Trastuzumab deruxtecan for treating HER2-low metastatic or unresectable breast cancer after chemotherapy