| Formulary Chapter 2: Cardiovascular system - Full Chapter
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| Chapter Links... |
 Academic Health Science Network (North East and North Cumbria) - Atrial Fibrilation |
| County Durham and Darlington DVT Pathway Information |
| County Durham and Tees Valley Prescribing Guideline for the Use of Anticoagulants in Non-Valvular Atrial Fibrillation |
| NICE NG148: Acute kidney injury: prevention, detection and management |
| NICE NG191: COVID-19 rapid guideline: managing COVID-19 |
| North Cumbria - Cardiovascular workplan 2022 |
| South Tees Hospitals Cardiology drug prescribing guidelines & formulary |
| Details... |
| 02.08.01 |
Parenteral anticoagulants |
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Argatroban
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Formulary
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- For use on advice of haematologists in patients with heparin induced thrombocytopenia.
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| 02.08.01 |
Heparin |
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Heparin
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Formulary
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| 02.08.01 |
Low molecular weight heparins |
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Enoxaparin (Inhixa®)
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Formulary
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- Use during pregnancy and for pre-operative bridging therapy .
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Venous thromboembolic diseases: diagnosis, management and thrombophilia testing
Venous thromboembolism in over 16s: reducing the risk of hospital-acquired deep vein thrombosis or pulmonary embolism
Shared Care Guideline (CUMBRIA ONLY) - Low Molecular Weight Heparin (LMWH) - Enoxaparin
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Tinzaparin
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Formulary
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- Use during pregnancy and for pre-operative bridging therapy
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Venous thromboembolic diseases: diagnosis, management and thrombophilia testing
Venous thromboembolism in over 16s: reducing the risk of hospital-acquired deep vein thrombosis or pulmonary embolism
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| 02.08.01 |
Heparinoids |
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Danaparoid
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Formulary
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- For use on advice from haematologists in patients who develop thrombocytopenia with heparins - cross reactivity with heparin antibodies is thiought to be <10%.
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| 02.08.01 |
Hirudins |
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Bivalirudin
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Formulary
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- Approved for preventing thrombosis in patients undergoing percutaneous coronary artery interventions.
- For use instead of abciximab in some low risk patients.
- Approved in combination with aspirin and clopidogrel for the treatment of adults with ST segment elevation MI undergoing percutaneous coronary intervention, in accordance with NICE guidance.
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NICE NG185: Acute coronary syndromes
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| 02.08.01 |
Heparin flushes |
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Heparin
(Flush)
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Formulary
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- 50 units in 5ml & 200 units in 2ml – for flushing cannulae
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TauroHep®
(Taurolidine and citrate catheter lock solution with heparin)
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Formulary
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- Approved for use in the prevention of central intravenous line infections
in; haemodialysis patients, adult parenteral nutrition patients, patients with recurrent line infections, and immune deficiency unit patients.
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TauroLock®
(Taurolidone and citrate catheter lock solution)
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Formulary
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- Approved for use in the prevention of central intravenous line infections in; haemodialysis patients, adult parenteral nutrition patients, patients with recurrent line infections, and immune deficiency unit patients.
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| 02.08.01 |
Epoprostenol |
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Epoprostenol
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Formulary
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- For pulmonary hypertension see section 2.5.1
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Iloprost
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Formulary
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- Mainly for use in treating pulmonary hypertension - see secton 2.5.1
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| 02.08.01 |
Fondaparinux |
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Fondaparinux
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Formulary
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- Approved for high risk orthopaedic surgery pateints and as an alternative to enoxaparin in accordance with NICE guidance.
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Venous thromboembolic diseases: diagnosis, management and thrombophilia testing
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Key |
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Cytotoxic Drug
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Controlled Drug
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High Cost Medicine
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NHS England |
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Homecare |
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CCG |
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Traffic Light Status Information
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Drugs for hospital use only. The responsibility for initiation and monitoring treatment should rest with an appropriate hospital clinician and the drug should be supplied through the hospital throughout the duration of treatment.
In some very exceptional circumstances (e.g. due to distance from the hospital, storage, supply or mobility/transport problems) it may be appropriate for the GP to be asked to prescribe a Red drug. This should be negotiated on an individual patient basis and should only be done with the GP’s prior informed agreement where the roles of the GP and hospital services are clearly defined and agreed. The GP should not feel under pressure to prescribe in these circumstances.
For all RED drugs automatically added to the formulary in response to a positive NICE TA: Prescribers need to ensure that local Trust new drug governance procedures and pharmacy processes are followed before any prescribing. |
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Drugs initiated by hospital specialist, but where continuing treatment by GPs may be appropriate under a shared care arrangement.
The specialist should send the GP a copy of the shared care agreement to sign. The GP should sign the shared care agreement, or indicate they do not want to be part of such an agreement, and return a copy back to the specialist. Shared care guidelines are available or are being developed for most of the drugs listed as Amber.
If no shared care guideline is available, the hospital specialist should provide the patient’s GP with sufficient information and support to allow treatment to be continued and managed safely in primary care. |
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Drugs normally recommended or initiated by a specialist (hospital or GP with an extended role https://www.rcgp.org.uk/gpwer), but can be safely maintained in primary care with very little or no monitoring required. In some cases there may be a further restriction for use outlined - these will be defined in each case. Provision of additional information, or an information leaflet, may be appropriate in some cases to facilitate continuing treatment by GPs. |
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Drugs where prescribing by GPs is appropriate. Can be initiated and prescribed in all care settings, and if appropriate, discontinued without recourse to secondary care. |
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NOT APPROVED: Drugs that have been considered by NTAG or the NENC ICB Medicines Subcommittee (or other approved body) and are not approved for prescribing within the North East and North Cumbria. |
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UNDER REVIEW: drugs whose current formulary status or RAG status is currently under review. |
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NOT REVIEWED: Drugs that haven not been reviewed yet. This usually means that an application is in progress. These drugs are not normally considered appropriate for prescribing in the North East and North Cumbria until such time that a decision is taken on their formulary status. |
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